Using Wine introduces new threats to your Linux box. One day every computer virus prepared to run under Windows will smoothly run under Wine. Some time ago I wrote ClamFS, a FUSE-based user-space file system for Linux with on-access anti-virus file scanning. It uses well known Open Source virus scanner – Clam AntiVirus. ClamFS was designed to protect Samba shares and FTP servers with upload enabled. Here is small guide how to configure ClamFS to protect Wine installation form viruses.